Abstract: Aiming at the surface scale formed during high temperature hot forming process of TC4 titanium alloy, the influence of laser cleaning process on the cleaning effect, surface hardness, tensile properties, corrosion resistance and surface element composition of titanium alloy were separately studied by optical microscope, scanning electron microcopy, HV-1000 Vickers hardness tester, Instron 8801 tensile testing system, CS electrochemical workstation and EPMA-8050G electron probe microanalyzer.The test results show that the laser cleaning process could remove the high-temperature scale on the surface of titanium alloy.The surface microhardness of titanium alloy increases by 8.5% (from 286.33 HV to 310.65 HV).The tensile strength and yield strength increase respectively by 1.8% and 4.3%. The proportion of surface oxygen content decreases by 87.7% and the surface corrosion rate is 18.3% of titanium alloy without laser cleaning. The laser cleaning technology can effectively replace the traditional high-temperature NaOH cleaning process in the aeronautical field.